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One has to keep in mind that leptin takes part in the pathophysiology of both asthma and obesity and that outcomes of these diseases may overlap, especially in the context of lung function [156,192,193,194]

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For example, intradiscal injection of bone morphogenetic protein-2 (BMP-2) induced degenerative changes [92] and weekly intradiscal treatment with growth and differentiation factor-5 (GDF-5) or insulin-like growth factor-1 (IGF-1) resulted in inflammatory reactions in the adjacent vertebrae and connective tissue infiltrates in the NP, causing the IVD to collapse [93]