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Juices in the stomach break the GSH molecule into its three constituting amino acids glutamate, L-cysteine, and glycine which must then be reassembled into GSH

While ETC activity drives pro-ferroptotic ROS generation via electron leakage, it is also essential for anti-ferroptotic enzymes (e.g., DHODH and GPD2) that reduce mitochondrial coenzyme Q (CoQ) to ubiquinol (CoQH 2 ) (113115)

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It remains unclear whether distinct death signals are activated sequentially, in parallel, or undergo context-dependent modulation at the single-cell or population level-particularly across different respiratory epithelial subtypes and immune cell populations under diverse stress conditions

Published online February 21, 2020 DOI: 22,014 View 322 Download 102 Web of Science 105 Crossref Abstract PDFPubReader ePub Mitochondrial medicine is increasingly discussed as a promising therapeutic approach, given that mitochondrial defects are thought to contribute to many prevalent diseases and their complications