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In the alternate pathway, activity of the C27 hydroxylase is preceded by that of 12 hydroxylase (CYP8B1), which adds a third hydroxyl group to the steroid nucleus, ultimately yielding the tri-hydroxy bile acid, cholic acid

In FM, melatonin has been shown to improve sleep quality, pain levels, and the pain threshold by enhancing the descending endogenous pain-modulating system [63]