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To this end, we developed an in-silico approach combining both unbiased identification of transcriptional signatures associated with oligodendroglial formation (i.e., transcriptomes) and knowledge-driven curation of transcriptional changes associated with oligodendrogenesis (i.e., OligoScore)

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[5] Adrenal Dysfunction Adrenal dysfunction (also known as adrenal fatigue ) can result from an overloaded immune system (as explained in the Immune Overload section above), as well as from imbalances in cortisol production and steroid levels