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Moreover, increasing evidence suggests that glutamate treated HT22 cells lack caspase activation and glutamate induced cell death proceeds independently of the bcl-2 family proteins so in this cell line glutamate induced apoptosis is mediated via the caspase independent pathway which involves calpain and AIF and is accompanied by DNA ladder formation but not chromatin condensation (Zhang and Bhavnani, 2006)

doi: 10.1080/14779072.2018.1497974

We propose a mechanistic link where altered regulation of CD98HC-dependent activities in the absence of ATM explains some of the poorly understood clinical manifestations of A-T

Statements Author contributions CZ: Writing original draft, Writing review and editing

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