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549 The reactive astrocytes can promote excitotoxic injury of motor neurons by producing nitric oxide and peroxynitrite, which cause mitochondrial damage and apoptosis in cultured neurons, decreasing glutamate transport, releasing pro-apoptotic mediators selectively toxic to motor neurons

Many adverse events attributed to peptides trace back to contaminated research-grade products

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Patients with the highest BDNF response also showed the best improvement in motor performance and functional independence as assessed by Barthel index scores

Karege F, Vaudan G, Schwald M, Perroud N, La Harpe R