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Analysis of cerebrospinal fluid (CSF) in AD patients reveals a significant increase in total FFA levels, although individual lipid species show distinct patterns of alteration (69)

Lipid peroxides released early during ferroptosis act as damage-associated molecular patterns (DAMPs), promoting dendritic cell (DC) maturation and antigen cross-presentation, which in turn primes CD8 + T cells and enhances anti-tumor immunity ( + T cells and DCs, thereby positioning CDH4 as a promising target for combination therapies leveraging ferroptosis and immunotherapy

Despite this model relies on strong immune components, which is assured by B cell expansion and T cell activation, the presence of typical cell types of innate immunity like the neutrophil is widely documented

A decrease in GABA in the thalamus and dorsolateral PAG (dl-PAG) was reported after oxaliplatin treatment in rats that was accompanied by signs of CIPN (Xu et al., 2018)

doi: 10.1038/s41420-022-01206-y