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Treatment with pemetrexed continued until RECIST v1.1 (modified to follow a maximum of 10 target lesions and a maximum of 5 target lesions per organ)-defined progression of disease as determined by the investigator or unacceptable toxicity

You can read the full article at NeuroSearch is developing a compound called NS-2330, which enhances the activity of dopamine, norepinephrine, and acetylcholine