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Description

Xu and Messina, 2009

These findings promote the hypothesis of melatonin acting against SQSTM1/p62, the cargo receptor that incites autophagic degradation or clockophagy of BMAL1/ARNTL and, by extension, the resulting ferroptosis [374]

Next, we exploited the E603Q form also for the structural studies, as this substitution in NaAtm1 has been shown to stabilize an occluded conformation 30