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Discovery of a novel prolyl-tRNA synthetase inhibitor and elucidation of its binding mode to the ATP site in complex with l-proline

Intracellular ROS measurement LNCaP cells were seeded at 6 10 4 cells/well in 24-well plates, adhered overnight and then incubated with conditioned media for 2.5 days before treatment with doxorubicin or taxol

Clinical and radiological details were recorded

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De Pasquale R, Beckhauser TF, Francis-Oliveira J (2016) Reactive Oxygen Species: Physiological and Physiopathological Effects on Synaptic Plasticity