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Myelin Synthesis and Neural Transmission B12s Role in Myelin: Essential cofactor for myelin sheath formation Myelin insulates nerve fibers Enables fast, efficient neural transmission In B12 Deficiency: Demyelination occurs Slower neural conduction Impaired neurotransmitter signaling Even if serotonin is present, signals dont transmit efficiently Clinical Correlation: SSRIs increase synaptic serotonin But if nerves are demyelinated, signal transmission is impaired B12 repletion supports myelin integrity Enhances the neuronal response to increased neurotransmitter availability 4

When folic acid is not ingested in the diet by those with adequate nutritional status, the bodys storage capacity can be maintained for at least 3 months without deficiency 28

Do's Apply an ice pack every hour for at least 15 minutes to reduce the pain and discomfort

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Absorption of the majority of the nutrients takes places in the jejunum, with a few exceptions: iron is absorbed in the duodenum, and vitamin B12 and bile salts are absorbed in the terminal ileum