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The cause of rosacea is unclear, but susceptible individuals are thought to have the following: Immune system dysregulation Heightened reactivity of the facial blood vessels, making them prone to inflammation and damage Abnormalities in skin connective tissue composition, leading to skin barrier defects and blood vessel wall weakening and dilation Hair follicle and oil gland structural defects aggravated by inflammation Hypersensitivity to specific microbial species, which is thought to be linked to eye symptoms and papule and pustule formation Rosacea flare-ups usually have triggers

This is assessed before treatment

Johnson et al., 2009)

A 5 mg vial and a 30 mg vial of the same formulation degrade at the same rate under the same conditions

2023;25:e3550