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added that APOE- 4 is a risk factor, and that patients that are homozygous to this allele will be 8 times more prone to develop AD (Yokoyama et al., 2017)

The application of multi-OMICS approaches are gaining acceptance in the regulatory community to provide information on a chemicals hazard and risks though their mode-of-action (MOA), however, its utility in a AOP building context are still limited

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In skin cell and animal research models, it has been studied for its ability to upregulate the genes responsible for producing collagen and elastin - the structural proteins that give tissue its strength and elasticity

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