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A larger study by the Hanson group employed machine learning to distinguish ME/CFS patients from healthy controls with 79.1% accuracy (AUROC value 0.891) using only seven proteins (Giloteaux et al., 2023)

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This method has significant potential for administering macromolecular medications and vaccinations, which are otherwise constrained by the skins barrier properties

This platform recruits effector proteins containing the FYVE/PX domain, which promote the assembly of pre-autophagosomal structures (28)

However, with physiologic HNE concentrations, induction of GCLC required Nrf2 signaling (Zhang et al., 2007)