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For the second category, manufacturers of herbal medicines are required to demonstrate that the safety and effectiveness of the traditional herbal medicinal product are based on long-standing medicinal use: 30 years worldwide, including at least 15 years in the European Union (Wachtel-Galor and Benzie, 2011)

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8 Multimodal imaging-guided and integrated immunotherapy Following the successful use of COFs for therapeutic intervention, microenvironment modulation, and drug delivery, a critical next challenge arises: how to visualize and evaluate the ongoing immune battle within the tumor in real time