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In this way, the folate cycle is blocked and a functional folate deficiency develops (folate trap) [3,34]

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* * * * * (C) * * * ( 12 ) Beginning with the 2026 MIPS payment year, CMS determines, based on documentation provided to the agency on or before November 1st of the year preceding the relevant MIPS payment year, that data for a MIPS eligible clinician are inaccessible or unable to be submitted due to circumstances outside of the control of the clinician because the MIPS eligible clinician delegated submission of the data to their third party intermediary, evidenced by a written agreement between the MIPS eligible clinician and third party intermediary, and the third party intermediary did not submit the data for the performance category on behalf of the MIPS eligible clinician in accordance with applicable deadlines

Plasmid construction All plasmids were constructed using either restriction enzyme cloning or Gibson assembly

A further increment in the concentration of each compound resulted in a substantial reduction in the percentage of viable cells by comparison to control (no treatment) (Table S6, Fig