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Mutations in IDO2 are common in the population, but the elevation in tryptophan, likely triggered by multiple factors such as stressors and pathogens, is rarer and is the potential cause of ME/CFS

Non-pharmacological interventions include medication adjustment

Food and Drug Administration (FDA) as rigorously as medications are, and too much of certain vitamins can cause health problems

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SMT15 protein targets to the chloroplast To investigate where SMT15 protein is delivered to exert its function, we attempted but failed to generate a HA tagged full-length SMT15 cDNA construct for localization study