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Evidence ledger: major claims graded What most pages get wrong about IGF-1 LR3 vs tesamorelin The "same axis" oversimplification: Most comparison content treats these as interchangeable tools for the same job because both ultimately involve IGF-1 signaling

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J Neurosci 38(15):38403857

After thrombin cleavage (1 nM -thrombin overnight at 4 C) to remove the His 6 tag, the sample was applied to a Superdex-75 (GE Healthcare Life Sciences) equilibrated in NMR buffer (50 mM bis-tris, pH 6.5, 50 mM NaCl, 1 mM DTT)