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PMC 1682953

Antioxidant pathway studies: Copper cofactor activity supports superoxide dismutase (SOD), a key enzyme protecting keratinocytes from free radical damage and oxidative stress

investigated two of Chiles southernmost berries, murtha and calamansi, and identified them as fruits with high ORAC values and natural antioxidant properties ( 3.3.2 TRAP Marge Kartau et al

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Other novel therapeutic approaches for PAH include suppression of activin receptor type IIA signalling with sotatercept, which has shown substantial efficacy in clinical trials and was approved for use in the USA in 2024, but the long-term safety of the drug remains unclear