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In major depressive disorder (MDD) and other depression-like conditions, it is still hypothesized that serotonin concentration, which is abnormally reduced, is the main factor [93]

In many cases, reducing or stopping the supplement may lead to gradual improvement

[67] Recent studies suggest that taking the selective serotonin reuptake inhibitors (SSRIs) antidepressants paroxetine (Paxil), fluoxetine (Prozac), and sertraline (Zoloft) can decrease the effectiveness of tamoxifen, as these drugs compete for the CYP2D6 enzyme which is needed to metabolize tamoxifen into its active forms

Pendleton was born in Campbell, Virginia