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3 In the United States (US), kratom use has proliferated in the past decade and is used typically in the form of capsules, powdered leaves consumed either dry or as a tea, in energy drinks, and in elixirs

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Given the complexity of mechanisms involved in drug resistance and survival pathways of tumor cells, combination strategies of GSH-conjugates with conventional chemotherapy or targeted drugs should provide very interesting perspectives for the treatment of drug resistant tumors

FIGURE 1 We review below general PKC function in relation to psychiatric illness with a focus on drugs affecting PKC pathways, with emphasis on the function of PRKCG, given its almost exclusive presence in neural tissue

Supplementary material The Supplementary Material for this article can be found online at: References 1 GuoWWangXLuBYuJXuMHuangRet al