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Troncone and Ferguson, 1988), particularly humanised models that are transgenic for several human genes relevant to the disease, such as NOD.DQ8/A 0 (Galipeau et al, 2011), hCD4.DR3-DQ2.MHCII / (de Kauwe et al, 2009), and DQ8-D d -IL-15tg (DePaolo et al, 2011) mice

This likely contributes to the fatigue most patients experience

Surprisingly, in the germ-free mice the effect of estrogen deficiency in gut permeability and cytokines dysregulation was ablated