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Topically applied curcumin (5 mg in Vaseline cream) significantly elevates Nrf2, HO-1, and SOD levels in mouse skin (WU et al., 2023), while nanocarrier-loaded curcumin (10 g/mL) synergistically upregulates Glutathione Peroxidase one and Nrf2 expression (Liakopoulou et al., 2025)

Excessive animal fat intake may increase the risk of chronic situations such as hyperlipidemia and hypertension (Basak et al., 2022)

10 Clinical observations and small-scale studies have suggested potential benefits, including reduced tinnitus severity, alleviation of comorbid symptoms such as anxiety and insomnia, and improved overall quality of life

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Several clinical trials have demonstrated that commonly used SGLT2i, including canagliflozin, dapagliflozin, and empagliflozin, can slow down kidney disease progression and reduce morbidity and mortality in patients with CKD, regardless of the presence of diabetes mellitus [155,156,157,158]