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The calculation method of binding energy is shown in Equation 1, W 1 represents the binding energy, W 1 represents the total energy of the interacting system, W 2 and W 3 represents the two independent molecules energy of Probe and the five toxic heavy meals, respectively

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To catalyze this oxidoreduction reaction, GLDH, as a typical dehydrogenase, employs cytochrome c (Cyt c) as an electron acceptor, forming a transient (millisecond lifetime) low-affinity protein-protein complex (Hervs et al., 2013), but cannot use molecular oxygen as an electron acceptor because the enzyme has an Ala113 acting as a gatekeeper, which prevents the molecular oxygen from accessing to the isoalloxazine nucleus (Leferink et al., 2009a)

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Some laboratories also maintain digital copies of certificates of analysis or product specification sheets so that these documents are always available during audits or internal reviews

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