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The pirfenidone 2400-mg group had an intermediate change in eGFR ( 1.9 6.7 ml/min per 1.73 m 2 ) that was not significantly different from that of the placebo arm [221]

In the usual course of things, a promising drug candidate would be ushered into human trials

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One of the major contributors in the inflammatory cascades is the high mobility group box 1 protein (HMGB1), which is overexpressed during neuroinflammation

doi: 10.1016/j.cca.2021.10.018 116 ZhaoYLiMTianXXieJLiuPYingXet al