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Given these findings, the present study concludes that Vans effects are largely evident in stress-induced or disease conditions and not in normal models, which aligns with the present observations of no behavioral or biochemical changes in healthy control animals

Therefore, defective Notch pathway alters keratinocytes proliferation and differentiation program, compromises apocrine gland homoeostasis and switches the fate of outer root sheath hair follicle cells, converting it into keratin-enriched epidermal cysts, a typical phenotypic trait of HS [45, 51, 52]

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doi:10.1016/j.jacc.2021.07.030 Libby P, Pasterkamp G, Crea F, Jang IK