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Structurally, BPC-157 is notable for a proline-rich backbone (five Pro residues, including a Pro-Pro-Pro triad) together with two acidic Asp residues, one Glu, a single basic Lys, and a hydrophobic C-terminal Leu-Val motif, giving the sequence a distinctive residue distribution relevant to secondary-structure modeling, chromatographic behavior, and mass-spectral fragmentation patterns

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Over time, insulin resistance can be joined by declining beta-cell function, so the pancreas can no longer meet demand

2008 May 15;453(7193):314-21

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