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The mice were maintained and treated in accordance with the Association for Research in Vision and Ophthalmology Statement for the Use of Animals in Ophthalmic and Vision Research

This causes an increase in the production of additional inflammatory cytokines, which in turn causes the inflammatory responses to become more intense (Kelley et al

doi: 10.3390/nu16010154 114

Hedges' g effect values of 0.20, 0.50 and 0.80 respectively represent small, medium and large effects ( Meta-analysis was performed using R Studio's Metafor package ( I 2 statistics for quantification and Cochran's Q for statistical significance test to evaluate heterogeneity

Moreover, surface-bound plasmin may counteract complement as demonstrated for diverse human pathogenic bacteria 8,49,62,63