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Besides acting as an intermediate in an active DNA demethylation pathway, 5hmC may also serve as a stable neuronal epigenetic mark in its own right [43]

10.1371/journal.pone.0193731 387

Randomized phase II, double-blind, placebo-controlled study of exemestane with or without entinostat in postmenopausal women with locally recurrent or metastatic estrogen receptor-positive breast cancer progressing on treatment with a nonsteroidal aromatase inhibitor