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Morphine differentially affects ventral tegmental and substantia nigra brain reward thresholds

There are several underlying reasons for the methyl trap: the concentration of Hcy drops, oxidative stress inhibits MS, and the drop in [SAM] releases the inhibition of MTHFR, which drives more folate towards the 5mTHF form

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The HPLCCMEAS allows quantitative assays of hundreds to thousands of low molecular-weight metabolites, in turn permitting identification of biomarkers and metabolic maps associated with disease processes

Hsu LC, Bendel RE, & Yoshida A (1978) Genomic structure of the human mitochondrial aldehyde dehydrogenase gene