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Polyphenols can damp down inflammatory signaling, modulate nutrient sensing pathways, and induce the selective apoptosis of senescent cells

doi: 10.1038/s41392-020-00428-9 150 KamMCaliezJNunesHGilleT

Although a detailed description of PPI is beyond the aim of our review, such network partially recapitulates the peculiar crosstalk and close association between the intrinsic biological clock and the intracellular signaling pathways described above, with relevant implications in the therapeutic management of diseases

Corticosteroids primarily alleviate symptoms by exerting potent anti-inflammatory and immunosuppressive effects, with their core mechanism involving the inhibition of key transcription factors, which subsequently reduces the production of pro-inflammatory cytokines (Singh et al., 2025)