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R in each case 2 Independently is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, nitrogen protecting group, or a group of formula (i), (ii) or (iii)

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and cisplatin given 12 h later, led to a fourfold increase in survival of patients, in comparison with patients treated with the same dose of both drugs at the same time (6 p.m) 129,130

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