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Copper in brain, besides participating in specific functions mentioned earlier, is also associated with general metabolism, which includes energy metabolism (cytochrome c oxidase, TCA cycle (FDX1)), antioxidant defense (superoxide dismutase containing zinc and copper, copper blue protein), iron metabolism (copper blue protein), neurotransmitter synthesis (dopamine--monooxygenase), and neuropeptide synthesis (peptide glycine--amidating enzyme) (Liu L

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