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The amount of iNOS and COX2 were normalized with respective -actin level and expressed as % non-LPS control (middle panel)

VSMC proliferation and intimal thickening also predispose individuals to oscillatory or low blood flow, which have been shown to induce leukocyte adhesion, enhanced vascular permeability, LDL oxidation, and atherosclerotic plaque formation 42,43,44

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Together, these findings support a mechanistic dissociation in which early adversity preferentially perturbs PFC bioenergetic regulation, with comparatively weaker or distinct effects in the NAc

The effective discovery of natural antioxidant sources requires reliable methods for evaluating antioxidant activity