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The substantial gap between preclinical evidence and clinical validation represents the primary limitation for evidence-based clinical use

29,179,281 Therefore, developing SIRT1-targeted therapies requires careful optimization of dosing, precise control of activity levels, stage-specific intervention timing, tissue- or cell-targeted delivery systems, and integration of NAD + status monitoring to minimize risks and achieve effective outcomes

[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Cunha, A., Gaubert, A., Latxague, L

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Donations will fuel support groups, treatment options and integrative therapies