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After discovering that NO-affecting 15-hydroperoxy-eicosa-tetra-enoyl-phosphatidylethanolamine produced by 15-lipoxygenase (15-LOX) modulate the ferroptosis endurance in M1 macrophages [60], researchers further found that ROS like O2 and NO uses the same entry pores and channels connecting to 15-LOX-2 catalytic site for competition [61]

Curcumin acts synergistically with fluconazole to sensitize a clinical isolate of Candida albicans showing a MDR phenotype

This suggests that the different linker sequences and crystal lattice packing do not significantly perturb the structures of the target proteins, further validating the linker design strategy