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Molecular cloning and characterization of a rice dehydroascorbate reductase

doi: 10.1080/15548627.2022.2062887 178 XieSSDengYGuoSLLiJQZhouYCLiaoJet al

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A CRISPR/Cas system mediates bacterial innate immune evasion and virulence

Hence, even now, and despite the knowledge that APAP can cause hepatotoxicity in overdose, and the extensive research that has been conducted on its pharmacokinetics and mechanisms of toxicity over the years, there is still no quantitative model for predicting de novo the dose level at which hepatotoxicity will occur in humans and how this will vary with metabolic activity.70 Ultimately the decision to progress the development of APAP would then come down to potential risk versus benefit