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doi: 10.1038/s41395-018-0222-5 97 GreeneCConnollyRBrennanDLaffanAOKeeffeEZaporojanLet al

Gene expression and genetic variation in response to endoplasmic reticulum stress in human cells

Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) see dose-dependent increases, promoting the blood vessel formation necessary to support new tissue growth

Erythrocytes have a limited metabolizing ability to pantothenate, and they are used probably only as a pantothenate transporter to other tissues

Future studies could explore strategies such as ligand or antibody modifications to enhance active targeting, ensuring precise delivery of carriers to target regions and effective release of drugs to maximize PPEs bioactivities