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The rationale is that glucagon also increases energy expenditure and promotes hepatic fat mobilization, so a molecule that combines glucagons metabolic-rate effect with GLP-1/GIPs appetite-and-glucose control can, in principle, drive weight loss from both sides of the energy-balance equation at once

The dual-mechanism approach may also offer specific advantages for particular patient subgroups, including those with type 2 diabetes and obesity where cardiometabolic improvements beyond weight loss are clinically important