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Preclinical toxicology studies in rodents showed no significant hepatotoxicity, nephrotoxicity, or hematologic abnormalities at doses equivalent to 100200mg daily in humans

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For three or more groups, when the main issue was whether a significant difference between groups and whether there are interactions between factors, one-way ANOVA or Kruskal Wallis ANOVA was performed depending on normality

This article does not assert that combining them produces additive or synergistic effects in any model system