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Direct Chemical Antioxidant Activity: The A-ring of the E2 molecule itself is a phenolic hydroxyl structure, which gives it the potential to act as a chain-breaking antioxidant capable of directly scavenging lipid peroxyl radicals

Mother of all antioxidants

Other reasons include: bariatric surgery or bowel resection, age, those with GI diseases such as Crohns and Celiac, people taking Metformin to control their blood sugar and thos taking proton pump inhibitors (Prevacid, Prilosec, etc) for chronic heartburn

One of the most notable aspects of this metabolic reprogramming lies in one-carbon metabolism