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In addition, nobiletin treatment restored the reduced expression of some ferroptosis-related factors, including GPX4, SLC7A11, and TFR1 [248]

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It is hypothesized that inflammasome activation in KCs promotes the production of proinflammatory cytokines, such as interleukin-1 (IL-1), which subsequently activate HSCs, leading to extracellular matrix deposition and the development of liver fibrosis ( Schistosoma species that affect humans

Tumor-intrinsic Wnt/-catenin signaling reduces CC motif chemokine ligand 4 (CCL4) secretion and thereby limits recruitment of basic leucine zipper ATF-like transcription factor 3 (Batf3)-dependent CD103 + (cDC1) cross-presenting DCs, which is associated with immune exclusion and poor CD8 + priming [143]