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Alpha-2-macroglobulin (A2M) is highly upregulated upon microbial infection and involved in several immune pathways ( alpha-2 macroglobulin in the hemolymph and hepatopancreas showed that a decline trend from the stage AB to stage E may suggest that the A2M was not necessarily to participate in the immune defense during the molting cycle of crab

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Conditions known to be associated with Paradoxical B12 deficiency include: Chronic Fatigue Syndrome Fibromyalgia Myalgic Encephalitis Autism Down Syndrome Cerebral Palsy (Bottinger etal, 2020) Insufficient intake of vitamin B2, Iodine, Selenium and/or Molybdenum Hypothyroidism Rheumatoid arthritis Cystic fibrosis Conditions which are associated with functional B2 deficiency, or where Paradoxical B12 deficiency should be suspected Gestational diabetes Obesity Diabetes Conditions of elevated serum vitamin B12 levels above the norm

Zhong, J., Dong, J., Ruan, W

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