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Zn deficiency can result in growth stunting, affecting the skin, gastrointestinal tissues, the immune system, the skeletal system, and the reproductive systems most severely (20)

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455 Future research should elucidate how aberrant sensory afferent activity interacts with maladaptive CNS plasticity to initiate and sustain neuropathic pain

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Folic acid corrects the hematologic manifestations of pernicious anemia, while the neurologic complications progress, potentially causing irreversible central nervous system effects