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More generally, the consensus of an international lipid expert panel is that evidence for use of either a single or combination lipid-lowering nutraceutical is limited and variable, but that berberine may have benefit for prevention, particularly in patients with mild hypercholesterolemia who are statin-intolerant or have metabolic syndrome (24)

Systemic effects remain less certain because peptides are generally broken down during digestion, which reduces the amount that reaches circulation in active form

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How to Supplement Thoughtfully If you have addressed the foundations and decide that supplementation is the right next step, follow these principles to ensure you are being intentional: Start Low and Go Slow: Introduce one new supplement at a time

Statistical analyses were conducted using GraphPad Prism 8.0 software (Dotmatics)