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The role of Kaposis sarcoma-associated herpesvirus/human herpesvirus-8 regulator of transcription activation (RTA) in control of gene expression

PAL exhibits strong inducibility under stress conditions, enhancing the synthesis of all phenolic compounds, including phytoalexins, thereby serving as a primary adaptive response to a number of biotic and abiotic stressors [177]

Both coffee (Reference Ludwig, Clifford and Lean2) and tea (Reference Khan and Mukhtar3) contain several beneficial components including polyphenols such as lignans and chlorogenic acid and epigallocatechin gallate, which are believed to be associated with a lower risk of site-specific cancers, CVD and premature death (Reference Poole, Kennedy and Roderick4,Reference Yi, Wu and Zhuang5)

Studies have shown that ONOO can impair mitochondrial-ATP synthesis through inhibition of mitochondrial respiratory complexes, mitochondrial polarization, and detoxifying enzymes in addition to promoting mitophagy 65,66

Brault, S