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5 Novel targeted drugs Advancements in understanding the pathophysiological mechanisms of DN have led to the development of novel targeted therapies aimed at specific molecular pathways involved in nerve damage and pain transmission (Table 1 and Fig

Studies in subjects with cancer demonstrated both decreased and increased plasma concentrations of free TRP, suggesting alterations in its entry into the brain and serotonin synthesis, which can play a role in behavior, mental functions, and onset of anorexia-cachexia syndrome [212,213,214,215]

Riboflavin is essential for breaking down proteins, fats, and carbohydrates

Iron homeostasis, complement, and coagulation cascade as CSF signature of cortical lesions in early multiple sclerosis

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