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Redox-Dependent Modifications of Keap1 as Molecular Switch in PD Keap1 interacts with several other redox-sensitive signaling pathways that modulate the activity of the NLRP3 inflammasome

[DOI] [PubMed] [Google Scholar] 396.Travaline JM, Sudarshan S, Roy BG, Cordova F, Leyenson V, Criner GJ

At this point, a full media replacement occurred including fresh growth factor in the presence or absence of test agent

In contrast, the relatively fast oxidation rate of OxyR combined with its slow reduction kinetics eases the sustained oxidation of the transcription factor upon mild to severe H 2 O 2 threats, so that OxyR is maintained in the active form long enough to exert its antioxidant role as a transcription factor

Inside the SCN, several single-cell circadian oscillators are coordinated to provide regular circadian outputs