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In Ser-GSTs, the GSH thiol group is normally hydrogen bonded to the hydroxyl group of the catalytic serine (Ser13 in PtGSTF1) (Pgeot et al., 2014)

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However, mTORC1 activation only promoted metabolic reprogramming of Gclc -deficient FoB but was not sufficient to ensure antibody production, in contrast to B cell cells isolated from tuberous sclerosis complex 1 (TSC1)-deficient mice 102

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