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This sensitizing effect suggests that AS-IV may help mitigate cisplatin-induced toxicity by reducing the required dosage of the chemotherapeutic agent, thereby alleviating cardiotoxicity during cisplatin therapy

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2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino)- phenylcarbamoylsulfanyl]propionic acid and its derivatives as a novel class of glutathione reductase inhibitors